Genetic tests can help show if members of certain families have inherited a high risk of colorectal cancer due to inherited cancer syndromes such as Lynch syndrome (also known as hereditary non-polyposis colorectal cancer, or HNPCC) or familial adenomatous polyposis (FAP).
Can you test for colon cancer gene?
Colon cancer genetic testing is a blood test that can tell you whether you carry rare changed, or mutated, genes that can cause colon cancer. Although most people who get colon cancer do not have one of these mutated genes, having them greatly increases your chance of getting colon cancer.
Does colon cancer usually run in families?
Most colorectal cancers are found in people without a family history of colorectal cancer. Still, as many as 1 in 3 people who develop colorectal cancer have other family members who have had it. People with a history of colorectal cancer in a first-degree relative (parent, sibling, or child) are at increased risk.
One in 18 individuals (5.5 percent) will develop colon cancer in their lifetime. Of all colon cancer cases, only about 5 to 10 percent are hereditary, linked to gene mutations inherited from one’s mother or father.
How much does genetic testing for colon cancer cost?
Those who are found to have a gene mutation associated with Lynch syndrome could then take the necessary precautions to prevent cancer, such as earlier colonoscopy screenings. The cost to screen a high-risk individual is approximately $2,600.
What gene causes colon polyps?
Mutations in the APC gene cause both classic and attenuated familial adenomatous polyposis. These mutations affect the ability of the cell to maintain normal growth and function. Cell overgrowth resulting from mutations in the APC gene leads to the colon polyps seen in familial adenomatous polyposis.
When should you suspect Lynch syndrome?
When should you suspect Lynch syndrome? You should suspect Lynch syndrome if a patient has a family history of cancer, especially if there are: Three or more family members, one of whom is a first-degree relative of the other two, with HNPCC-related cancer. Two successive affected generations.
What is the main cause of colon cancer?
The exact cause of colorectal cancer is not known, but certain risk factors are strongly linked to the disease, including diet, tobacco smoking and heavy alcohol use. Also, people with certain hereditary cancer syndromes or a family history of colorectal cancer have a high risk of developing the disease.
What are my chances of getting colon cancer?
Overall, the lifetime risk of developing colorectal cancer is: about 1 in 23 (4.3%) for men and 1 in 25 (4.0%) for women. A number of other factors (described in Colorectal Cancer Risk Factors) can also affect your risk for developing colorectal cancer.
Are colon polyps inherited?
Family history. You’re more likely to develop colon polyps or cancer if you have a parent, sibling or child with them. If many family members have them, your risk is even greater. In some people, this connection isn’t hereditary.
Is genetic testing for cancer covered by insurance?
Most private insurers cover genetic testing for inherited mutations. Under the Patient Protection and Affordable Care Act (ACA), genetic counseling and BRCA testing for women with specific personal and/or family cancer history should be covered with no co-payment.
Is genetic testing a good idea?
Genetic testing is useful in many areas of medicine and can change the medical care you or your family member receives. For example, genetic testing can provide a diagnosis for a genetic condition such as Fragile X or information about your risk to develop cancer. There are many different kinds of genetic tests.
How do you know if you have the brca1 gene?
The BRCA gene test is most often a blood test. A doctor, nurse or medical technician inserts a needle into a vein, usually in your arm, to draw the blood sample needed for testing. The sample is sent to a lab for DNA analysis. In some cases, other sample types are collected for DNA analysis, including saliva.