Reactive lesions such as Kikuchi lymphadenitis, infectious mononucleosis, autoimmune lymphoproliferative syndrome, and immunoglobulin G4-related sclerosing disease can be misdiagnosed as lymphomas.
What could be mistaken for lymphoma?
Benign etiologies of lymphadenopathy can include infections, autoimmune disorders, drug hypersensitivity reactions, sarcoidosis, and amyloidosis. Rare but benign lymphoproliferative disorders include Kikuchi’s disease, Rosai-Dorfman disease, and progressive transformation of germinal centers.
How often is lymphoma misdiagnosed?
The Non-Hodgkin’s Lymphoma Classification Project. Thus, 5% of patients with common B-cell lymphomas and up to 20–40% of patients with less common lymphoma types might be inaccurately diagnosed.
Can symptoms of lymphoma be something else?
Symptoms That Overlap With Other Conditions
Many symptoms of lymphoma are also present in other, less serious illnesses, such as an infection like the flu or a common cold. These shared symptoms might include swollen lymph nodes, fatigue, fever, tiredness, and other signs.
What looks like lymphoma but isn t?
Castleman disease is a rare condition that happens when too many cells grow in your lymph nodes, the small organs that filter out germs. After a while, hard growths form. Castleman disease isn’t cancer. But it can act a lot like lymphoma, a cancer of the lymph nodes.
Does lymphoma show in bloodwork?
Blood tests aren’t used to diagnose lymphoma, though. If the doctor suspects that lymphoma might be causing your symptoms, he or she might recommend a biopsy of a swollen lymph node or other affected area.
Can an infection mimic lymphoma?
Unfortunately, these biopsies can lead to a misdiagnosis of lymphoma, as involvement of lymphoid tissue by acute EBV infection can resemble both Hodgkin lymphoma and non-Hodgkin lymphoma.
What were your first symptoms of non-Hodgkin’s lymphoma?
Signs and Symptoms of Non-Hodgkin Lymphoma
- Enlarged lymph nodes.
- Weight loss.
- Fatigue (feeling very tired)
- Swollen abdomen (belly)
- Feeling full after only a small amount of food.
- Chest pain or pressure.
- Shortness of breath or cough.
Can you get a false positive for lymphoma?
Inaccurate staging of lymphomas and a false-positive diagnosis may occur as a result of FDG uptake in association with nonspecific inflammatory lymph nodes. Lack of increased metabolic activity within enlarged nodes has been shown to correlate well with lack of tumor involvement.
What is the most common early symptom of lymphoma?
The most common sign of lymphoma is a lump or lumps, usually in the neck, armpit or groin. These lumps are swollen lymph nodes, sometimes known as ‘glands’. Usually, they’re painless. Fatigue is different to normal tiredness.
Can lymphoma be misdiagnosed as mono?
In the case of atypical presentation, lymph node and tonsillar biopsies are required to rule out lymphoma [3,4]. However, biopsies can lead to misdiagnosis, as acute EBV in lymphoid tissue can mimic both Hodgkin’s and non-Hodgkin’s lymphoma (NHL) resulting in inappropriate diagnosis and treatment [2,5].
Is it hard to diagnose lymphoma?
Hodgkin lymphoma (HL) may be difficult to diagnosis. You may want to get a second medical opinion by an experienced hematopathologist before you begin treatment.
How long can you have lymphoma without knowing?
These grow so slowly that patients can live for many years mostly without symptoms, although some may experience pain from an enlarged lymph gland. After five to 10 years, low-grade disorders begin to progress rapidly to become aggressive or high-grade and produce more severe symptoms.
What will your CBC look like with lymphoma?
CBC measures certain parts of your blood, including: Red blood cells, which transport oxygen throughout the body. If lymphoma disrupts red blood cell production in the bone marrow, you may have a low red blood cell count, or anemia. White blood cells, which fight infection.
Where does lymphoma usually start?
Lymphomas can start anywhere in the body where lymph tissue is found. The major sites of lymph tissue are: Lymph nodes: Lymph nodes are bean-sized collections of lymphocytes and other immune system cells throughout the body, including inside the chest, abdomen, and pelvis.
Is lymphoma malignant or benign?
Lymphoma is a type of tumor that starts in white blood cells called lymphocytes, and when it is not cancerous, it is called benign lymphoma, pseudolymphoma, or benign lymphoid hyperplasia (BLH).