ErbB2-intronic MicroRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling | Cell Death & Disease.
Is ERBB2 a tumor suppressor gene?
A series of recent works has shed new light on the regulation of ERBB2 in mammary epithelial cells. Expression of this gene is apparently tightly controled by a number of transcriptional repressors. FOXP3 represses ERBB2 expression, and acts as a tumor suppressor when inactivated .
How does ERBB2 cause cancer?
Overwhelming evidence from numerous studies indicates that amplification or overexpression of ErbB2 disrupts normal cell-control mechanisms and gives rise of aggressive tumor cells.
What is an example of tumor suppressor?
Examples of tumor suppressor genes are the BRCA1/BRCA2 genes, otherwise known as the “breast cancer genes.” People who have a mutation in one of these genes have an increased risk of developing breast cancer (among other cancers).
Is HER2 an oncogene or tumor suppressor?
HER2 is a proto-oncogene found on chromosome 17. It encodes a protein and functions as a cell membrane receptor (see Figure 1). HER2 is one of a family of 4 structurally related receptors. The HER family plays an important role in regulating cell growth, survival, and differentiation in a complex manner.
What is ERBB2 mutation?
More recently, activating mutations in the ERBB2 gene have been increasingly reported in multiple solid cancers and were shown to play an oncogenic role similar to that of ERBB2 amplification. Thus, ERBB2 mutations define a distinct molecular subtype of solid tumors and serve as actionable targets.
Is ERBB2 an RTK?
The ErbB receptor tyrosine kinase family (RTK class I) consists of four cell surface receptors: ErbB1/EGFR/HER1, and ErbB2-4/HER2-4. ERbB receptor tyrosine kinases have important roles in human cancer.
Is HER2 and ERBB2 the same?
The HER2 is the legacy gene symbol for ERBB2 and may be more commonly used by the community; HER2 is also commonly used to describe the protein encoded by the ERBB2 gene. One unique feature of HER2 compared with the other receptors in the HER family is the absence of a known ligand.
What is ERBB2 in breast cancer?
Estrogen receptor (ER), progesterone receptor (PR), and c-ERBB2 (HER2/neu) are therapeutically and prognostically important markers in the management of breast carcinoma. About 60% to 70% of breast carcinomas express ER protein, and these tumors are associated with better prognosis.
What does ERBB2 code for?
Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene isolated from avian genome.
Is p53 a tumor suppressor gene?
The p53 gene is a type of tumor suppressor gene. Also called TP53 gene and tumor protein p53 gene.
What are different tumor suppressor genes?
Like p53, the INK4 and PTEN tumor suppressor genes are very frequently mutated in several common cancers, including lung cancer, prostate cancer, and melanoma. Two other tumor suppressor genes (APC and MADR2) are frequently deleted or mutated in colon cancers.
What are examples of proto oncogenes?
Examples of proto-oncogenes
- Ras. The first proto-oncogene to be shown to turn into an oncogene is called Ras. …
- HER2. Another well-known proto-oncogene is HER2. …
- Myc. The Myc gene is associated with a type of cancer called Burkitt’s lymphoma. …
- Cyclin D. Cyclin D is another proto-oncogene.
Is BRCA1 a tumor suppressor gene?
BRCA1 and BRCA2 are sometimes called tumor suppressor genes because when they have certain changes, called harmful (or pathogenic) variants (or mutations), cancer can develop.
What is HER2 gene amplification?
HER2/neu gene is the most frequently amplified gene in breast cancer (in 20~30% of cases) . Its amplification and overexpression are associated with poor prognosis and resistance to cytotoxic drugs in breast cancer patients [4–6].
Who makes trastuzumab?
Genentech: Herceptin® (trastuzumab) – Information for Patients.